United States securities and exchange commission logo August 15, 2022 Ebun Garner General Counsel Erasca, Inc. 3115 Merryfield Row, Suite 300 San Diego, California 92121 Re: Erasca, Inc. Registration Statement on Form S-3 Filed August 11, 2022 File No. 333-266802 Dear Mr. Garner: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Conlon Danberg at 202-551-4466 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Matthew T. Bush, Esq.