United States securities and exchange commission logo





                         August 15, 2022

       Ebun Garner
       General Counsel
       Erasca, Inc.
       3115 Merryfield Row, Suite 300
       San Diego, California 92121

                                                        Re: Erasca, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed August 11,
2022
                                                            File No. 333-266802

       Dear Mr. Garner:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Conlon
Danberg at 202-551-4466 with any questions.




                         Sincerely,


                         Division of Corporation Finance

                         Office of Life Sciences
       cc:                                              Matthew T. Bush, Esq.